Lei GUO received his B.S. degree in mathematics from Shandong University in 1982, and Ph.D. degree in control theory from the Chinese Academy of Sciences in 1987. He was a postdoctoral fellow at the Australian National University (1987-1989). Since 1992, he has been a Professor of the Institute of Systems Science at the Chinese Academy of Sciences (CAS), where he had been Director of the Institute (1999-2002). From 2002 to 2012，he was the President of the Academy of Mathematics and Systems Science, CAS. He is currently the Director of the National Center for Mathematics and Interdisciplinary Sciences, CAS.

Dr. Guo was elected Fellow of the IEEE in 1998, Member of the Chinese Academy of Sciences in 2001, Fellow of the Academy of Sciences for the Developing World (TWAS) in 2002, Foreign Member of the Royal Swedish Academy of Engineering Sciences in 2007, and Fellow of the International Federation of Automatic Control (IFAC) in 2007 “for fundamental contributions to the theory of adaptive control and estimation of stochastic systems, and to the understanding of the maximum capability of feedback”. In 2014, he was awarded an honorary doctorate by Royal Institute of Technology (KTH), Sweden. His coauthored paper on synchronization of flocks was selected and published as a SIGEST Paper by SIAM Review in 2014. He was also the recipient of the 1993 IFAC World Congress Young Author Prize “for solving a long standing problem in control theory concerning convergence and convergence rate for the least-squares–based self-tuning regulators”. He was awarded the 2019 Hendrik W.Bode Lecture Prize by the IEEE Control Systems Society  "for fundamental and practical contributions to the field of adaptive control, system identification, adaptive signal processing, stochastic systems, and applied mathematics". He has delivered twice plenary lectures at the IFAC World Congress in 1999 and 2014 respectively, and was an Invited speaker at the International Congress of Mathematicians (ICM) in 2002. He has also been selected as a distinguished lecturer of the IEEE Control Systems Society (2012-2014).

He has served as a Council Member of IFAC (2005-2011),Member of IEEE Control Systems Award Committee (2008-2011, 2018-2020), Member of the IFAC Award Committee (2005-2008, 2017-2020), Associate Editor of SIAM J. Control and Optimization (1991-1993), General Co-Chair of the 48th IEEE Conference on Decision and Control (2009), Deputy Director of the CAS Academic Committee (2013-2018), Congress Director of the 8th International Congress on Industrial and Applied Mathematics (ICIAM 2015), Advisor of the National Basic Research Program of China (2011-), President of the China Society for Industrial and Applied Mathematics (CSIAM), Vice-President of the Chinese Mathematical Society, and Vice-President of the Chinese Association of Automation. Currently, he serves as the Director of the Information Science Division of CAS Academic Committee (2018-), Director of the Division of Information Technology, CAS (2021-), and a member of editorial boards of a number of academic journals in mathematics, systems and control.

He has worked on problems in adaptive control, system identification, adaptive signal processing, and stochastic systems. His current research interests include control of nonlinear uncertain systems, PID control theory, distributed filtering and estimation, capability of feedback, multi-agent systems, game-based control systems, and complex systems, among others.